140 Рђрѕрѕрѕсѓ Site

Because its levels fluctuate heavily depending on the presence of tumors, tracking miR-140 expression quantities in tissue is actively researched as a way to predict clinical outcomes and survival rates in patients with neoplasia.

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MicroRNA-140 is highly expressed in cartilage and is a master regulator of chondrocytes (the cells responsible for cartilage formation). Because its levels fluctuate heavily depending on the

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Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix.

It is necessary for normal endochondral ossification, the process by which the growing skeleton is formed. Mice lacking this gene often exhibit dwarfism and craniofacial abnormalities due to impaired chondrocyte proliferation.

A breakthrough study published in Nature discovered that a "gain-of-function" mutation in the miR-140 gene leads to a severe, novel autosomal dominant human skeletal dysplasia. 🔬 Function in Cancer and Therapeutics