Nucleoside Reverse Transcriptase Inhibitor -

NRTIs function as "prodrugs," meaning they are inactive upon entry and require by host cell kinases to become active triphosphate metabolites. Once activated, their mechanism follows two critical steps:

Because NRTIs lack a 3'-hydroxyl group, once they are incorporated into the growing viral DNA strand, no further nucleotides can be added. This prematurely stops the conversion of viral RNA into DNA, preventing the virus from replicating. Commonly Used NRTIs nucleoside reverse transcriptase inhibitor

Clinically approved NRTIs are frequently used in combination therapies to improve efficacy and reduce the risk of drug resistance. Notable examples include: NRTIs function as "prodrugs," meaning they are inactive