Because the imaging is non-invasive, researchers can scan the same animal over days or weeks. This reduces the number of animals needed for a study and provides a more accurate timeline of how a tumor grows or shrinks in response to treatment. 🛠 Features and Workflow
PearlCAM is the proprietary interface used to capture and analyze high-resolution images in the spectrum. Unlike visible light, NIR light can penetrate several centimeters into biological tissue, allowing for:
Biological tissues naturally glow under certain light; the NIR range used by PearlCAM minimizes this "noise," resulting in much clearer images. PearlCAM
The subject is placed in the imaging chamber. PearlCAM software captures the NIR signal and overlays it on a standard grayscale "white light" image for anatomical context.
The software quantifies the signal intensity, allowing researchers to say exactly how much of a drug reached the target compared to healthy tissue. 🌟 Why It Matters Because the imaging is non-invasive, researchers can scan
Before a new cancer drug or imaging agent can be tested on humans, it must be proven effective and safe in animal models. Systems like the LI-COR Pearl Trilogy provide the high-quality data required by regulatory bodies (like the FDA) to move a discovery from the lab to the clinic.
A fluorescent probe (like IRDye®) is injected into the subject. Unlike visible light, NIR light can penetrate several
💡 Many researchers prefer the Pearl system because it uses a One-Touch imaging approach—eliminating the need for complex camera adjustments and making the technology accessible even to those without a background in physics.