Meredith treats a patient from her past, a therapist who develops a medically impossible 24-inch blood clot. Their conversations lead Meredith to realize she is projecting her anger about Nathan Riggs' situation—specifically that he got his "lost love" (Megan Hunt) back while she never will.

Dr. Tom Koracick informs her that the tumor likely explains years of her erratic behavior and impulsive judgment calls.

Owen spends time with his sister, Megan, who calls him out on his general unhappiness, while Owen remains frustrated by Amelia’s distant behavior. Watch a short overview of the episode's key moments: Go Big or Go Home Grey's Anatomy YouTube• Oct 6, 2017

is the third episode of Grey's Anatomy Season 14 . The plot centers on several high-stakes personal and professional medical crises at Grey Sloan Memorial Hospital. Amelia's Secret

Amelia initially keeps the diagnosis a secret from her husband, Owen, and her colleagues, struggling with an identity crisis as she wonders how much of her personality was actually the tumor.

The intimidating Harper Avery arrives at the hospital, putting Miranda Bailey on edge as he threatens to pull funding.