: Bonnie Swanson has to leave town to visit her ailing father, leaving Joe and their baby, Susie, alone.
: The split of Stewie into a docile side and a purely evil side heavily mimics the classic Star Trek episode "The Enemy Within" , complete with the original dramatic score. [S9E12] The Hand That Rocks the Wheelchair
: Meg begins wearing Bonnie's dresses and referring to Joe by his first name. When she learns Bonnie is returning, Meg steals Joe's gun and frames Bonnie by planting it in her luggage at the airport. : Bonnie Swanson has to leave town to
: The final freeze-frame shot with Stewie turning to the camera with yellow monster eyes is a direct reference to the end of the legendary "Thriller" music video. When she learns Bonnie is returning, Meg steals
: At a local park, Stewie's ray gun misfires when he tries to seek revenge on a bully. Feeling that he has "lost his edge" as a brilliant, evil baby, he builds a neural-enhancement machine to restore his malice.
: Jennifer Tilly (who voices Bonnie) has her character mention that she needs voice-over checks to pay for her gambling addiction, a direct nod to Tilly's real-life success as a professional poker player.