Tm,cc,jp May 2026

The study highlights that membrane binding involves a cooperative effort of multiple domains.

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions tm,cc,jp

This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs. The study highlights that membrane binding involves a

It tethers vesicles to the plasma membrane, facilitating sound encoding. facilitating sound encoding.