In a climactic showdown that pits old-world predators against modern genetic monstrosities, the island's original queen—the Tyrannosaurus Rex—is unleashed. The battle for Isla Nublar ends in a chaotic display of nature’s power, proving once again that life cannot be contained.

When the Indominus proves to be far more intelligent and lethal than anticipated, it staged a brilliant escape, vanishing into the dense jungle. Desperate to contain the threat, Claire enlists the help of Owen Grady, a rugged ex-Navy ethologist who has spent years training a pack of .

The park’s manager, Claire Dearing, is focused on the bottom line. To keep corporate sponsors happy and attendance high, the lab has engineered a new "attraction": the , a genetic hybrid designed to be bigger, louder, and more terrifying than a T-Rex.